From the category archives:

Latest News/Advances

Advancing technology gives rise to newer methods of healing. In the field of dentistry, the major development is taking place in methods of regenerating gum tissue. Gum tissue is vital in supporting teeth and holding them in place.

The latest development by Scientists at the University of Michigan, for regenerating gum tissue is a technique that uses gene delivery. This method of gene delivery looks safe and does not seem to pose any hazards for regenerating gum tissue that supports teeth. According to William Giannobile, a professor at the U-M School of Dentistry, there still remain many issues that revolve around concern for safety of the patient undergoing gene therapy, though this form of therapy is accepted widely as a method of treatment and healing.

This concern for safety was highlighted in the early stages of its development a number of years ago, when a teenager undergoing gene therapy died after the administration of adenovirus during a gene therapy clinical trial at the University of Pennsylvania.


Gene therapy versus U-M therapy

When he compared gene therapy to U-M therapy, Professor Giannobile said that both therapies use adenovirus but in U-M therapy, the dosage is much lower and treatment is in the form of a local application, quite like a paste which is applied directly on the tissue during surgery; as opposed to gene therapy where the genes are injected directly in the blood vessels which allows adenovirus to travel in the blood stream and this may at times result in unexpected developments which can sometimes be fatal. The U-M method is more of a topical method where the adenovirus is controlled in the localised area and is not allowed to spread throughout the body. This approach lessens concerns of saftey and about negative reactions that may occur within the body.

Professor Giannobile, who has an appointment at the U-M College of Engineering’s Department of Biomedical Engineering and also directs the Michigan Center for Oral Health Research, explained that the teenager died, as the adenovirus got into his bloodstream and he reacted adversely to it. It was tragic.

He said that in the first study of periodontal disease therapy, it was demonstrated the that distribution of these genes was very safe. He also said that it could be used in the clinic for clinical application. He said that their study does not address all the safety concerns, but that safety was surely a very important concern to the field. (The success of using this treatment will surely depend on its safety factor.) The U-M method of treatment shows great potential in clinical treatment of Periodontal disease and diabetic wounds. He pointed out that that this could be due to the fact that both these diseases are a result of a “defective healing environment.”

{ Comments on this entry are closed }

Bile Acids used for Dental Fillings

by admin on June 15, 2009

Technology today is truly advancing by leaps and bounds especially in the field of dentistry.
Currently materials made from mercury or plastic are used to fill up cavities in teeth. These are raising concerns among people as they could prove to be toxic to the human body.

In their ongoing research, Scientists in Canada and China have developed an enduring material using human bile acids. They hope that this material can be used to fill dental cavities. Bile acids, as we learnt in school, are body substances that the liver produces in order to help in the digestion of fats. Bile acids produced by the liver are stored in the gallbladder.

The description of the process in which these researchers collected human bile acids and proceeded to convert these acids into sturdy, tough, durable plastic kind of material that is hard and resistant to cracking, has appeared in an article in ACS (Applied Materials & Interfaces). This article also states that the newly developed material using human bile acids is much better at resisting cracking than the other materials that are currently in use.

The team of scientists working on this development are at the department of chemistry in the Shanxi University in China. They are led by Julian Zhu. They stated that this new material certainly seems stronger and longer lasting. They added that this material with its capacity to resist cracking, will certainly reduce the number of emergency visits to the dentist that could result due to cracked fillings which are rather painful.

{ Comments on this entry are closed }

Hot Cup of Tea Increase Throat Cancer Risk

May 31, 2009

Would You Expect To Get Throat Cancer By Drinking Hot Tea Every Day? Studies done in Britain do show that drinking extremely hot tea every day increases your chance of getting throat cancer. A correlated study done in Iran, which reportedly has the largest number of oesophageal cancer patients, shows the results of research done […]

Read the full article →

Link between HIV and Gum Disease says research

February 26, 2009

Japanese researchers have conducted a study which has found a link between HIV and gum disease. The study claims that gum disease produces an acid in the mouth which can favor the progression of HIV. This study will be published in the March issue of “Journal of Immunology”. This is the first time a link […]

Read the full article →

February – National Children’s Dental Health Month

February 3, 2009

February which is National Children’s Dental Health month has dawned upon us. Although not publicized as much, quite a few people of the community are aware of February being the National Children’s Dental Health. However not many are aware what this signifies. “So What?” is the typical reaction from the public when they are told […]

Read the full article →

Mouthwashes can cause cancer

January 18, 2009

A study conducted at University of Melbourne claims that mouthwashes containing alcohol can cause oral cancer and should be stopped from being sold to the public. The scientists who took part in the study claim that there is sufficient evidence to now indicate that alcohol containing mouthwashes increase the risk for oral cancer. It is […]

Read the full article →

4 Easy Steps to ensure good Dental Health for Kids

January 11, 2009

Dental care is an important area of concern for parents for their kids. This is especially because kids tend to neglect their dental health and require parental guidance for the same. Recent health statistics have indicated that around 25% kids in America aged between 2 and 5 have some kind of dental problem. This percentage […]

Read the full article →

Stem Cells from Wisdom Teeth

January 11, 2009

Japanese scientists have discovered that dental pulp from the wisdom teeth can be used as a source of therapeutic stem cells. This specific stem cell is known as mesenchymal stem cell. It is a totipotent stem cell which can develop in to other body tissues such as bone, cartilage and fat. This cell differs from […]

Read the full article →

Lavender Oil eases Dental Anxiety

January 11, 2009

Quite a few people are afraid of getting procedures done by a dentist. People tend to neglect their oral health due to fear of procedures such as tooth extraction or RCT. There exists quite a few ways to calm them and reduce dental anxiety before performing the procedure. A new approach in this regard is […]

Read the full article →

Gene Therapy to fight Gum Disease

January 11, 2009

Gene therapy can be used to fight against periodontal disease according to the scientists at University of Michigan who have studied the effect of gene therapy on periodontal disease (leading cause of tooth loss in adults). The study has been published online on December 11 prior to the print publication in Gene Therapy. Treating life […]

Read the full article →